Why did Sumire's summoning Nue act strangely in response to...

Isshiki being an enemy of Kaguya. So perhaps Nue sensed hostility and opposition from Kawaki’s karma seal? That is all the information we have for now. It’s possible that we will learn more about them later on.

I think that Nue was acting up due to its origins relating to Kaguya, whereas Kawaki’s Karma is from Isshiki.

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Why did Sumire's summoning Nue act strangely in response to Kawaki's karma?

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